{"id":533,"date":"2025-09-29T13:37:37","date_gmt":"2025-09-29T12:37:37","guid":{"rendered":"https:\/\/unv-ebolowa.cm\/?p=533"},"modified":"2025-10-07T10:54:50","modified_gmt":"2025-10-07T09:54:50","slug":"microbiologie-generale-et-toxicologie","status":"publish","type":"post","link":"https:\/\/unv-ebolowa.cm\/index.php\/en\/2025\/09\/29\/microbiologie-generale-et-toxicologie\/","title":{"rendered":"MICROBIOLOGIE GENERALE ET TOXICOLOGIE"},"content":{"rendered":"\n

Fili\u00e8re et option<\/strong> : Sciences Fondamentales de Bases Appliqu\u00e9es, Niveau 2 (Litt\u00e9raires)<\/p>\n\n\n\n

Nom du Responsable du cours : <\/strong>Dr MBOUOMBOUO Mama<\/p>\n\n\n\n

Disponibilit\u00e9 et contact :<\/strong> 690241655<\/p>\n\n\n\n

Date du cours ou p\u00e9riode du cours :<\/strong> Semestre 3 (octobre-f\u00e9vrier)<\/p>\n\n\n\n

D\u00e9coupage du cours (CM\/TD\/TP et TPE) :<\/strong> CM : 30 TD : 10 TPE : 5 Nombre de cr\u00e9dits :<\/strong> 3<\/p>\n\n\n\n

Description du cours<\/strong><\/p>\n\n\n\n

Ce cours offre une introduction compl\u00e8te aux principes fondamentaux de la toxicologie. Il couvre les concepts de base, les m\u00e9canismes d’action des toxiques, les m\u00e9thodes d’\u00e9valuation de la toxicit\u00e9, la toxicocin\u00e9tique et la toxicodynamique, ainsi que la toxicit\u00e9 sp\u00e9cifique \u00e0 diff\u00e9rents organes et syst\u00e8mes. Le cours aborde \u00e9galement les aspects r\u00e9glementaires et l’\u00e9valuation des risques li\u00e9s aux substances chimiques.<\/p>\n\n\n\n

Objectifs p\u00e9dagogiques :<\/strong><\/p>\n\n\n\n

1. D\u00e9finir les concepts fondamentaux de la toxicologie (toxicit\u00e9, dose, exposition, risque, etc.).<\/p>\n\n\n\n

2. D\u00e9crire les diff\u00e9rentes voies d’exposition aux toxiques et les facteurs qui influencent leur absorption, distribution, m\u00e9tabolisme et excr\u00e9tion (ADME).<\/p>\n\n\n\n

3. Expliquer les m\u00e9canismes d’action des toxiques au niveau mol\u00e9culaire, cellulaire et organique.<\/p>\n\n\n\n

4. Identifier les principaux organes cibles des toxiques et d\u00e9crire les effets toxiques sp\u00e9cifiques \u00e0 ces organes.<\/p>\n\n\n\n

5. D\u00e9crire les m\u00e9thodes utilis\u00e9es pour \u00e9valuer la toxicit\u00e9 des substances chimiques (\u00e9tudes in vitro, in vivo, \u00e9pid\u00e9miologique).<\/p>\n\n\n\n

6. Interpr\u00e9ter les donn\u00e9es toxicologiques et \u00e9valuer les risques li\u00e9s \u00e0 l’exposition aux substances chimiques.<\/p>\n\n\n\n

7. Comprendre les aspects r\u00e9glementaires de la toxicologie et les diff\u00e9rentes agences impliqu\u00e9es dans la gestion des risques chimiques.<\/p>\n\n\n\n

8. Appliquer les principes de la toxicologie \u00e0 des cas concrets d’exposition aux toxiques.<\/p>\n\n\n\n

9. \u00c9valuer de mani\u00e8re critique les informations toxicologiques provenant de diff\u00e9rentes sources.<\/p>\n\n\n\n

Contenu :<\/strong><\/p>\n\n\n\n

D\u00e9finition d’un toxique et formes d’intoxication, Les voies d\u2019expositions \u00e0 un toxique, Cheminement d\u2019un toxique dans l\u2019organisme, L\u2019effet toxique, Evaluation de la toxicit\u00e9 (d\u00e9termination des principaux param\u00e8tres de toxicit\u00e9) ; d\u00e9termination d\u2019une dose critique: DE50, DL50, CL50, NOAEL et LOAEL, valeurs limites biologiques (VLB) et  indicateurs biologiques d\u2019exposition (IBE).<\/strong><\/p>\n\n\n\n

Apprentissages cl\u00e9s :<\/strong><\/strong><\/p>\n\n\n\n

Comprendre les concepts fondamentaux de la toxicologie :<\/strong> les \u00e9tudiants seront capables de d\u00e9finir toxicologie, toxicit\u00e9, toxicodynamique, toxicocin\u00e9tique.<\/p>\n\n\n\n

Maitriser la notion de toxicit\u00e9<\/strong> : les \u00e9tudiants seront capables d\u2019\u00e9valuer la toxicit\u00e9 d\u2019une substance chimique ainsi que l\u2019effet toxique<\/p>\n\n\n\n

Programme et calendrier<\/strong><\/p>\n\n\n\n

Semaine\/date<\/td>Contenus\/objectifs<\/td>Activit\u00e9s<\/td>Travail pr\u00e9alable<\/td><\/tr>
Semaine 1<\/td>Notions g\u00e9n\u00e9rales en toxicologie<\/strong><\/td>G\u00e9n\u00e9ralit\u00e9s, historique D\u00e9finitions et classification des toxiques<\/td>Lecture des documents<\/td><\/tr>
Semaine 2<\/td>Les voies d\u2019expositions \u00e0 un toxique<\/strong><\/td>La voie digestive La voie respiratoire (Inhalation) La voie cutan\u00e9e (Peau) Diffusion des toxiques<\/td>Lecture et rappel du chapitre pr\u00e9c\u00e9dent<\/td><\/tr>
Semaine 3<\/td>Cheminement d\u2019un toxique dans l\u2019organisme<\/strong><\/td>Facteurs toxicodynamiques Facteurs toxicocin\u00e9tiques (ADME)  <\/td>Lecture et rappel du chapitre pr\u00e9c\u00e9dent<\/td><\/tr>
Semaine 4<\/td>L\u2019effet toxique<\/strong><\/td>D\u00e9finition : toxicit\u00e9, effet toxique Param\u00e8tres influen\u00e7ant l\u2019effet toxique Effets toxiques sur certains tissus et syst\u00e8mes biologiques Evolution d\u2019un effet toxique La classification des effets toxiques Relation dose effet toxique La dose Facteurs influen\u00e7ant l\u2019effet toxique Les interactions toxicologiques<\/td>Lecture et rappel du chapitre pr\u00e9c\u00e9dent<\/td><\/tr>
Semaine 5<\/td>Evaluation de la toxicit\u00e9<\/strong><\/td>Les diff\u00e9rentes formes de toxicit\u00e9 Evaluation de la toxicit\u00e9 aigu\u00eb syst\u00e9mique Evaluation de la toxicit\u00e9 aig\u00fce par voie locale<\/td>Lecture et rappel du chapitre pr\u00e9c\u00e9dent<\/td><\/tr>
Semaine 6<\/td>Travaux dirig\u00e9s <\/strong><\/td>Corrections des TDs et \u00e9changes en salle<\/td>Fiche de TD,<\/td><\/tr>
TPE <\/strong><\/td>Pr\u00e9sentation en salle<\/td>Th\u00e8me de recherche d\u00e9finit<\/td><\/tr>
Contr\u00f4le continu <\/strong><\/td>Evaluation \u00e9crite<\/td>\u00c9valuation sur le contenu du cours<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Mode d\u2019\u00e9valuation<\/strong><\/p>\n\n\n\n

Dates<\/td>Type d\u2019examen\/comp\u00e9tences vis\u00e9es<\/td>Pourcentage<\/td><\/tr>
Semaine 5<\/td>Travail Personnel de l\u2019\u00e9tudiant (expos\u00e9)<\/td>10%<\/td><\/tr>
Contr\u00f4le Continu : QCM, QRO<\/td>20%<\/td><\/tr>
Selon la programmation de l\u2019ISABEE<\/td>Examen \u00e9crit : QCM, QRO, \u00e9tude de cas<\/td>70%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

R\u00e8gles et fonctionnement du cours<\/strong><\/p>\n\n\n\n

R\u00e8gles g\u00e9n\u00e9rales<\/strong><\/p>\n\n\n\n

    \n
  • La pr\u00e9sence en cours est obligatoire et contr\u00f4l\u00e9e.<\/li>\n\n\n\n
  • Les \u00e9tudiants sont attendus pour participer activement aux discussions et aux activit\u00e9s en classe.<\/li>\n\n\n\n
  • Les \u00e9tudiants doivent respecter les d\u00e9lais de remise des travaux.<\/li>\n<\/ul>\n\n\n\n

    Retard dans la remise des travaux<\/strong><\/p>\n\n\n\n

      \n
    • Tout retard dans la remise des travaux sera p\u00e9nalis\u00e9 d’une fa\u00e7on suivante :<\/li>\n\n\n\n
    • 1 jour de retard : 10% de p\u00e9nalit\u00e9 sur la note finale<\/li>\n\n\n\n
    • 2 jours de retard : 20% de p\u00e9nalit\u00e9 sur la note finale<\/li>\n\n\n\n
    • 3 jours de retard : 30% de p\u00e9nalit\u00e9 sur la note finale<\/li>\n\n\n\n
    • Les \u00e9tudiants qui ne remettent pas leurs travaux dans les d\u00e9lais prescrits ne pourront pas obtenir une note sup\u00e9rieure \u00e0 60%.<\/li>\n<\/ul>\n\n\n\n

      Absent\u00e9isme<\/strong><\/p>\n\n\n\n

        \n
      • Tout absent\u00e9isme non justifi\u00e9 sera p\u00e9nalis\u00e9 d’une fa\u00e7on suivante :<\/li>\n\n\n\n
      • 1 absence non justifi\u00e9e : 10% de p\u00e9nalit\u00e9 sur la note finale<\/li>\n\n\n\n
      • 2 absences non justifi\u00e9es : 20% de p\u00e9nalit\u00e9 sur la note finale<\/li>\n\n\n\n
      • 3 absences non justifi\u00e9es : 30% de p\u00e9nalit\u00e9 sur la note finale<\/li>\n<\/ul>\n\n\n\n

        Travail personnel<\/strong><\/p>\n\n\n\n

          \n
        • Les \u00e9tudiants recevront des travaux personnels \u00e0 r\u00e9aliser entre les cours.<\/li>\n\n\n\n
        • Ces travaux seront not\u00e9s et compteront pour 10% de la note finale.<\/li>\n<\/ul>\n\n\n\n

          Plagiat<\/strong><\/p>\n\n\n\n

            \n
          • Tout plagiat sera s\u00e9v\u00e8rement p\u00e9nalis\u00e9.<\/li>\n<\/ul>\n\n\n\n

            Participation<\/strong><\/p>\n\n\n\n

              \n
            • Les \u00e9tudiants sont attendus pour participer activement aux discussions et aux activit\u00e9s en classe.<\/li>\n<\/ul>\n\n\n\n

              Bibliographie et ressources compl\u00e9mentaires<\/strong><\/p>\n\n\n\n

              ADAMCZYK E , ROQUE-BURONFOSSE F, PINEAU X, HUGNET C, TAVERNIER L, BOUCHAGOUR N et QUEFF\u00c9LEC S, 2015.<\/p>\n\n\n\n

              L\u2019intoxication au raisin chez le chien. Le Nouveau Praticien V\u00e9t\u00e9rinaire canine-f\u00e9line<\/em>. Vol. 13, n\u00b0 60, pp. 47-50.<\/p>\n\n\n\n

              BAISE E, HABYARIMANA J.A, AMORY H. et BOEMER F, 2016. Samaras and seedlings of Acer pseudoplatanus are potential sources of hypoglycin A intoxication in atypical myopathy without necessarily inducing clinical signs. Equine Veterinary Journal. <\/em>Vol. 48, n\u00b0 4, pp. 414-417.<\/p>\n\n\n\n

              BATES N, RAWSON-HARRIS P et EDWARDS N, 2015. Common questions in veterinary toxicology. Journal of Small Animal Practice<\/em>. Vol. 56, n\u00b0 5, pp. 298-306.<\/p>\n\n\n\n

              BAUD F, GARNIER R.2017. Toxicologie clinique 6\u00e9me Edition. Lavoisier m\u00e9decine <\/em>.1654p .<\/p>\n\n\n\n

              BENYOUSSEF S, BELGUITH.J, HADIJI. R, 2016. Introduction \u00e0 l\u2019Enseignement de Toxicologie. \u00c9cole nationale de m\u00e9decine v\u00e9t\u00e9rinaire de Sidi Thabet, 58p
              <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

              Fili\u00e8re et option : Sciences Fondamentales de Bases Appliqu\u00e9es, Niveau 2 (Litt\u00e9raires) Nom du Responsable du cours : Dr MBOUOMBOUO Mama Disponibilit\u00e9 et contact : 690241655 Date du cours ou p\u00e9riode du cours : Semestre 3 (octobre-f\u00e9vrier) D\u00e9coupage du cours (CM\/TD\/TP et TPE) : CM : 30 TD : 10 TPE : 5 Nombre de cr\u00e9dits : 3 […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-533","post","type-post","status-publish","format-standard","hentry","category-cours"],"yoast_head":"\nMICROBIOLOGIE GENERALE ET TOXICOLOGIE - Universit\u00e9 d'Ebolowa<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/unv-ebolowa.cm\/index.php\/en\/2025\/09\/29\/microbiologie-generale-et-toxicologie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MICROBIOLOGIE GENERALE ET TOXICOLOGIE\" \/>\n<meta property=\"og:description\" content=\"Fili\u00e8re et option : Sciences Fondamentales de Bases Appliqu\u00e9es, Niveau 2 (Litt\u00e9raires) Nom du Responsable du cours : Dr MBOUOMBOUO Mama Disponibilit\u00e9 et contact : 690241655 Date du cours ou p\u00e9riode du cours : Semestre 3 (octobre-f\u00e9vrier) D\u00e9coupage du cours (CM\/TD\/TP et TPE) : CM : 30 TD : 10 TPE : 5 Nombre de cr\u00e9dits : 3 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/unv-ebolowa.cm\/index.php\/en\/2025\/09\/29\/microbiologie-generale-et-toxicologie\/\" \/>\n<meta property=\"og:site_name\" content=\"Universit\u00e9 d'Ebolowa\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=100088178885402\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-29T12:37:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-07T09:54:50+00:00\" \/>\n<meta name=\"author\" content=\"Majoie ATANGANA\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Majoie ATANGANA\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/unv-ebolowa.cm\\\/index.php\\\/en\\\/2025\\\/09\\\/29\\\/microbiologie-generale-et-toxicologie\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/unv-ebolowa.cm\\\/index.php\\\/en\\\/2025\\\/09\\\/29\\\/microbiologie-generale-et-toxicologie\\\/\"},\"author\":{\"name\":\"Majoie ATANGANA\",\"@id\":\"https:\\\/\\\/unv-ebolowa.cm\\\/#\\\/schema\\\/person\\\/d09da3f56b3ebef4f39faf8f8960acbe\"},\"headline\":\"MICROBIOLOGIE GENERALE ET TOXICOLOGIE\",\"datePublished\":\"2025-09-29T12:37:37+00:00\",\"dateModified\":\"2025-10-07T09:54:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/unv-ebolowa.cm\\\/index.php\\\/en\\\/2025\\\/09\\\/29\\\/microbiologie-generale-et-toxicologie\\\/\"},\"wordCount\":1002,\"publisher\":{\"@id\":\"https:\\\/\\\/unv-ebolowa.cm\\\/#organization\"},\"articleSection\":[\"Cours\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/unv-ebolowa.cm\\\/index.php\\\/en\\\/2025\\\/09\\\/29\\\/microbiologie-generale-et-toxicologie\\\/\",\"url\":\"https:\\\/\\\/unv-ebolowa.cm\\\/index.php\\\/en\\\/2025\\\/09\\\/29\\\/microbiologie-generale-et-toxicologie\\\/\",\"name\":\"MICROBIOLOGIE GENERALE ET TOXICOLOGIE - 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