CV – Dr PONE KAMDEM Boniface - Université d'Ebolowa

Statut :

Vacataire

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Biographie :

Poné Kamdem Boniface est enseignant vacataire au Département d’Agriculture d’Elevage et des Sciences Halieutiques à l’Institut Supérieur d’Agriculture, du Bois, de l’Eau et de l’Environnement à l’Université d’Ebolowa. Par ailleurs, Boniface exerce comme enseignant vacataire au Département de Pharmacognosie et de Biomolécules Actives, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé 1, Cameroun. Le docteur Poné a obtenu une licence, Maitrise et Master en Biochimie à l’Université de Dschang au Cameroun. Grâce à la bourse de recherche TWAS-CSIR (oct. 2010-déc. 2014), il obtient un Doctorat/PhD en Biotechnologie et Bioinformatique à l’Université Jawaharlal Nehru (JNU) en Janvier 2015, à New Delhi en Inde. Ensuite, il a effectué six années de stages postdoctoraux (2), d’abord en Chimie médicinale (Mars 2015-Mars 2017) à l’Institut de Chimie de l’Université Fédérale de Rio de Janeiro (Brésil) grâce à la bourse de recherche CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), puis en Chimie pharmaceutique (nov. 2017-déc. 2021) au Département de Pharmacie de l’Université de Sao Paulo (Brésil) grâce à la bourse de recherche FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo). Dr Poné a publié plus de 55 articles dans des revues scientifiques avec comité de lecture. Il a encadré une dizaine d’Etudiants du MINSANTE, en cycle de Techniciens de Pharmacie à l’Institut des Sciences et Technologies La Sapience (une école de l’Université de Ngaoundéré sis à Yaoundé) ou il est enseignant à temps partiel. Dr Poné est membre du Laboratoire de Phytobiochimie et d’Etude des Plantes Médicinales de l’Université de Yaoundé 1 depuis 2021. Il est membre du comité de rédaction du Journal « Natural Products Communications », rédacteur scientifique de « Journal of Pharmaceutical Research International » et examinateur de plusieurs revues scientifiques.

Spécialité :

Biochimie, Biotechnologie

Liste des cours dispensés :

IAA424 : Industrie alimentaire

Champs de recherche :

Isolement et la caractérisation des substances naturelles de plantes, Synthèse des substances organiques (flavonoïdes, coumarines, entre autres), et des nanomatériaux (nanoparticules et nanocomposites)Applications à la médecine : Identification des pharmacophores antibactériens, antifongiques et antiparasitaires Applications à l’agriculture : Prospection de biofertilisants et biopesticidesApplications à l’environnement : Traitement des eaux usées (traitement biologique et évaluation de la toxicité).

Liste de publications :

Publications Dans Les Journaux À Comité De Lecture Mbaku Ngoumou J, Ngouana V, Pone Kamdem B., Natacha Paule Marie Ndzie, Pinlap BR, Kamche Youbi A, Keilah Lunga P, Teponno RB, Azefack Tapondjou L, Fekam Boyom F (2025) Bioguided isolation, identification and activity evaluation of antibacterial compounds from Combretum rhodanthum Engl. & Diels. South African Journal of Botany. 180: 236-253. DOI : https://doi.org/10.1016/j.sajb.2025.02.044Tsouh Fokou PV, Pone Kamdem B., Appiah-Oppong R, Ngouana V, Bakarnga-Via I, Ntieche Woutouoba D, Flore Donfack Donkeng V, Tchokouaha Yamthe LR, Fekam Boyom F, Arslan Ateşşahin D, Sharifi-Rad J, Calina D (2025). An update on antitumor efficacy of catechins: From molecular mechanisms to clinical applications. Food Science and Nutrition. 13(4) e70169. DOI: 10.1002/fsn3.70169. Ngouana V, Mbaku Ngoumou J, Pone Kamdem B., Kamche Youbi A, Makemteu J, Tsakem Nangap MJ, Tenkeu AC, Fekam Boyom F (2025). Phytochemical screening, antiplasmodial and antioxidant activities of Combretum rhodanthum extracts. South Asian journal of parasitology 8 (2): 66-81. https://doi.org/10.9734/sajp/2025/v8i2214Dzoyem JP, Tsemeugne J, Pone Kamdem B., Foyou Meupiap R, Kuate BA, Mkounga P, Fekam Boyom F, Lyndy Joy McGaw (2025). Antibacterial, antibiofilm and anti-quorum sensing activities of 1,2,3,5-tetrazine derivatives linked to a benzothiazole moiety. BiorXiv. DOI: https://doi.org/10.1101/2025.01.14.632941Pinlap BR, Pone Kamdem B., Kamto ELD, Ngouana V, Melogmo Dongmo YK, Keilah Lunga P, Fekam Boyom F (2024).Extracts from Cardiospermum grandiflorum and Blighia welwitschii (Sapindaceae) reveal antibacterial activity against Shigella species. South African Journal of Botany, 164, 419-428. https://doi.org/10.1016/j.sajb.2023.12.010.Momo EJ, Nguimatsia F, Ateufouet Ngouango L, Lunga PK, Pone Kamdem B, Jazet Dongmo PM (2024) Eugenol-rich essential oils from flower buds and leaves of Syzygium aromaticum show antifungal activity against Candida and Cryptococcus species. Future Pharmacology 4(3): 449-465. https://doi.org/10.3390/futurepharmacol4030025Tchatat Tali MB, Dize D, Youbi Kamche A, Pone Kamdem B., Hassan S, Njanpa Ngansop CA, Tsouh Fokou PV, Laleu B, Duffy J, Fabrice Boyom F (2024).Discovery of a picomolar antiplasmodial pyrazole derivative from a broad antiparasitic screening of compounds from the MMV Open Access Global Health Priority Box. Publisher: F1000 Research Ltd. DOI: https://doi.org/10.12688/verixiv.197.1Mahel Batana FL, Ngouana V, Madiesse Kemgne EA, Pone Kamdem B., Tsakem Nangap MJ, Kemzeu R, Makemteu J, Dize D, Tsouh Fokou PV, Tenkeu AC, Keilah Lunga P, Teponno RB, Azefack Tapondjou L, Fekam Boyom F(2025). Antiplasmodial and antioxidant activity of Vernonia blumeoides, a medicinal plant used in Cameroon to treat malaria. Medicines. European Journal of Medicinal Plants. 36(2) 61-79. DOI: 10.9734/ejmp/2025/v36i21247 Pone Kamdem, B., Pinlap, B.R., Noumboue Kouamou, B.-L., Youbi Kamche, A., Kuate, B.A., Tsemeugne, J., Ngomo, O., Mkounga, P., Fekam Boyom, F. (2024) Repurposing synthetic acetaminophen derivatives containing a benzothiazole scaffold as an alternative therapy for infectious diarrhea caused by drug-resistant Shigella species. Future Pharmacology. 4(2), 420-436. https://doi.org/10.3390/futurepharmacol4020023Noumboue Kouamou B-L, Pone Kamdem B., Ngouana V, Tashie Ngwanguong E, Tsakem Nangap MJ, Listone Monelle Ngameni Nzeye, Yanick Kevin Dongmo Melogmo, Keilah Lunga P, Fekam Boyom F (2024).Crude extracts from Diospyros gilletii stem bark attenuates Shigella flexneri-induced diarrhoea in mice. Available at SSRN: https://ssrn.com/abstract=4823936; DOI : http://dx.doi.org/10.2139/ssrn.4823936Tanka Zuriatou Y, Odogu Ankoro N, Ngouana V, Tchinda Taghu FL, Lum Mforbesi A, Nguena-Dongue B-N, Nsami Ndi J, Pone Kamdem B., Keilah Lunga P, Fekam Boyom F. (2024).Green synthesis of Cocos nucifera-based nanomaterials and mechanistic basis of their antimicrobial action. BioMed 4 (1), 59-77. https://doi.org/10.3390/biomed4010005Tchinda Taghu FL, Pone Kamdem B., Ngouana V, Zuriatou Tanka Y, Yimgang VL, Nsami Ndi J, Keilah Lunga P, Fekam Boyom F, (2024). Biological synthesis and characterization of silver-doped nanocomposites: Antibacterial and mechanistic studies. Drugs Drug Candidates 3(1), 13-32; https://doi.org/10.3390/ddc3010002Dize D, Tchatat Tali MB, Njanpa Ngansop CA, Keumoe R, Madiesse Kemgne EA, Tchokouaha Yamthe LR, Tsouh Fokou PV, Pone Kamdem B., Hata K, Fekam Boyom F, (2024).Target-based 6-5 fused ring heterocyclic scaffolds display broad antiparasitic potency in vitro. Future Pharmacology. 4(1), 188-198. https://doi.org/10.3390/futurepharmacol4010013Nguimatsia F, Momo EJ, Keilah Lunga P, Lum Tamanji V, Pone Kamdem B., Jazet Dongmo PM (2024). Susceptibility patterns in Staphylococcus and Klebsiella causing nosocomial infections upon treatment with E-anethole-rich essential oil from Clausena anisata. Drugs and Drug Candidates 3 (1), 244-255. https://doi.org/10.3390/ddc3010014 Nguelo Talla, AC, Madiesse Kemgne EA, Ngouana V, Noumboue Kouamou B, Nzeye Ngameni LM, Pinlap BR, Dongmo Melogmo YK, Nguena-Dongue B, Pone Kamdem, B., Keilah Lunga P, Fekam Boyom F (2024). Anti-shigellosis activity and mechanisms of action of extracts from Diospyros gilletii stem bark. Drugs Drug Candidates 3(1), 256-274; https://doi.org/10.3390/ddc3010015 Avirdi E, Paumo HK, Pone Kamdem B., Singh MB, Kumari K, Katata-Seru L, Bahadur I (2023). Imidazolium-based ionic liquid-assisted silver nanoparticles and their antibacterial activity: Experimental and density functional theory studies. ACS Omega. 8(45): 42976-42986. doi: 10.1021/acsomega.3c06171. Avirdi E, Kamdem Paumo H, Pone Kamdem B., Babu Singh M, Kumari K, Katata-Seru LM, Bahadur I (2023). Influence of cation (imidazolium based ionic liquids) as “smart” stabilizers for silver nanoparticles and their evaluation as antibacterial activity on Escherichia coli, Staphylococcus aureus and Enterobacter cloacae. Journal of Molecular Liquids. 369, 120935. DOI : https://doi.org/10.1016/j.molliq.2022.120935Pone Kamdem B., Fekam Boyom F (2023). Current prospects of saponins as promising anti-Trypanosoma brucei compounds: Insight into the mechanisms of action. Current Drug Targets. 24(10): 838-855. DOI: 10.2174/1389450124666230719105147.Tchatat Tali MB, Pone Kamdem B., Tchouankeu JC, Fekam Boyom F (2023). Current developments on the antimalarial, antileishmanial, and antitrypanosomal potential and mechanisms of action of Terminalia spp. South African Journal of Botany. 156, 309-333. doi:10.1016/j.sajb.2023.03.028Nguena-Dongue B-N, Pone Kamdem B., Keilah Lunga P, Fekam Boyom F (2023). Ethnomedicinal uses, phytochemistry, and pharmacological activity of the Irvingia species. Drugs Drug Candidates 2(4), 827-864. https://doi.org/10.3390/ddc2040042Pone Kamdem B., Fekam Boyom F (2023). Inhibitors of farnesyl diphosphate synthase and squalene synthase: Potential source for anti-Trypanosomatidae drug discovery. Drugs Drug Candidates 2(3), 624-652. https://doi.org/10.3390/ddc2030032Kamto ELD, Zingue S, Grein T, Pone Kamdem B., Maxeiner S, Rutz J, Ngo Mbing J, Pegnyemb DE, Njamen D, Blaheta RA, Leitão GG(2023). Two Phenolic Compounds (Biscoumarin and Biflavonoid) From Ormocarpum kirkii S. Moore (Fabaceae) Exhibit Anticancer Properties Against Human Prostate Cancer Cells. Journal of Herbal Medicine. 42, 2023, 100811, https://doi.org/10.1016/j.hermed.2023.100811Pone Kamdem B., Kamto ELD, Soh D, Pegnyemb DE, Zingue S, Kamdem Paumo H, Katata-Seru LM, Abou A, Maiyane Rosinah M, Ajeck Mbah J, Fekam Boyom F(2023). Pharmacological activity and mechanisms of action of terpenoids from Laurus nobilis L. The Natural Products Journal. 13 (7) 1-18. DOI: 10.2174/2210315513666221208154957. Pone Kamdem B., Igne Ferreira E, Boyom Fabrice F (2022).The role of flavanones as scaffolds for the development of new treatments against malaria, African and American trypanosomiases. Mini Reviews in Medicinal Chemistry. 23(14) 1479-1498. DOI: 10.2174/1389557523666221229122543. Pone Kamdem B., Boyom Fabrice F, Kamdem Paumo H, Katata-Seru LM (2022). Protective roles and mechanism of action of plant flavonoids against hepatic impairment: Recent developments. Current Drug Targets. 24 (4), 332-360. DOI: 10.2174/1389450124666221227094958. Pone Kamdem B., Igne Ferreira E(2022). Therapeutic potential of flavonoid derivatives for certain neglected tropical diseases. Current Drug Targets. 23(7) 680-682. DOI: 10.2174/1389450123666220309093827. Eutrophe Le Doux Kamto, Pone Kamdem B., 2022, Pharmacological activity and mechanism of action of flavonoids from diverse Millettia plant organs. The Natural Products Journal. 12(7) 24–52. DOI: 10.2174/2210315512666220509114733. Tchamgoue J, Amelework NE, Pone Kamdem B., Ngandjui YAT, Tchouankeu JC, Kouam FS, Mekonnen Y, 2022. In vivo antiplasmodial properties of fractions and flavonoids of Pseudarthria hooheri Wight & Arn. (Fabaceae). Natural Resources for Human Health 2(3) 313-321. DOI: https://doi.org/10.53365/nrfhh/1454 Ngouana V, Tsouh Fokou PV, Donfack Donkeng VF, Kemzeu R, Dongmo Melogmo YK, Pone Kamdem B., Bakarnga-Via I, Jazet Dongmo PM, Fekam Boyom F (2022).Antifungal, antiradical and anti-inflammatory properties of four Euphorbiaceae species. Current Topics in Phytochemistry 18: 65-78.Pone Kamdem B., Igne FerreiraE (2021) The role of nitro (NO2-), chloro (Cl), and fluoro (F) substitution in the design of antileishmanial and antichagasic compounds. Current Drug Targets. 22 (4), 379-398. DOI: 10.2174/1389450121666201228122239. Pone Kamdem B., Dalhatou S, Kamdem Paumo H, Kataka-Seru LM, Igne Ferreira E (2021). Triazole-containing heterocycles: Privileged scaffolds in anti-Trypanosoma cruzi drug development. Current Drug Targets. 23(1) 33-59. DOI: 10.2174/1389450122666210412125643. Rebaone M, Kamdem Paumo H, Pone Kamdem B.,Katata-Seru LM(2021).In situ stabilisation of silver nanoparticles at chitosan-functionalised graphene oxide for reduction of 2,4-dinitrophenol in water. Polymers 13 (21) 3800. https://doi.org/10.3390/polym13213800. Kamdem Paumo H, Dalhatou S, Kataka-Seru LM, Pone Kamdem B.,Oladejo Tijani J, Vishwanathan V, Kane A, Bahadur I (2021). TiO2 assisted photocatalysts for degradation of emerging organic pollutants in water and wastewater. Journal of Molecular Liquids. 331, https://doi.org/10.1016/j.molliq.2021.115458.Pone Kamdem B., Eutrophe Le Doux Kamto, Hugues Kamdem Paumo, Lebogang Maureen Katata-Seru, Dieudonné Emmanuel Pegnyemg, Elizabeth Igne Ferreira, 2021. Chemical constituents, ethnomedicinal uses, pharmacology, and toxicity of Dysphania ambrosioides (L.) Mosyakin and Clemants, formerly Chenopodium ambrosioides L. The Natural Products Journal. 12 (3), 31-73. DOI: 10.2174/2210315511666210920144526.Pone Kamdem B., Kamto ELD, Aboubakar, Pegnyemb DE, Igne Ferreira E, (2021). Ethnomedicinal uses, phytochemistry, pharmacology, and toxicity of the genus Nymphaea L.: A review. Current Bioactive Compounds. 18 (8), 2-40. DOI: 10.2174/1573407218666220111110352. Santos SDS, Silva JV,Pone Kamdem B., Giarolla J, 2021. Amazon rainforest; a natural source for new therapeutic alternatives against Neglected Tropical Diseases. The Natural Products Journal. 12, 6, 20-34. DOI: 10.2174/2210315512666220228151415. Pone Kamdem B., Cinthya Miyuki Sano, Elizabeth Igne Ferreira (2020), Unveiling the targets involved in quest of antileishmanial leads using in-silico methods. Current Drug Targets. 21(7) 681-712. DOI: 10.2174/1389450121666200128112948. Pone Kamdem B., Igne Ferreira E (2020). An insight into the discovery of potent antifilarial leads against lymphatic filariasis. Current Drug Targets. 21(7) 657-680. DOI: 10.2174/1389450120666191204152415. Pone Kamdem B., Igne Ferreira E(2019). Flavones as a privileged scaffold in drug discovery: current developments. Current Organic Synthesis. 16(7): 968-1001. DOI: 10.2174/1570179416666190719125730.Pone Kamdem B., Igne Ferreira E, 2019. Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease and dengue. Phytotherapy Research, 33(10): 2473-2517. DOI: 10.1002/ptr.6383.Pone Kamdem B., Elizabeth Igne Ferreira, 2019. Flavonoid-derived privileged scaffolds in anti-Trypanosoma brucei drug discovery. Current Drug Targets 20(12): 1295-1314. DOI: 10.2174/1389450120666190618114857. Pone Kamdem B., Elizabeth Igne Ferreira, 2019. Opportunities and challenges for flavonoids as potential leads for the treatment of tuberculosis. BOOK CHAPTER. in Studies in Natural Products Chemistry (Bioactive Natural Products), Volume 65, 2020, Pages 85-124.Pone Kamdem B., Ferreira SB, Kaiser CR(2017). Current state of knowledge on the traditional uses, phytochemistry, and pharmacology of the genus Hymenaea. Journal of Ethnopharmacology 206, 193-223.DOI: 10.1016/j.jep.2017.05.024Pone Kamdem B. (2017). Advances on ethnomedicinal uses, phytochemistry, and pharmacology of Spathodea campanulata P. Beauv. EC Pharmacology and Toxicology 5, 51-62.Pone Kamdem B., Ferreira SB, Kaiser CR (2016). Recent trends in phytochemistry, ethnobotany and pharmacological significance of Alchornea cordifolia (Schumach. & Thonn.) Muell. Arg. Journal of Ethnopharmacology 191, 216-244.doi: 10.1016/j.jep.2016.06.021.Pone Kamdem B., Innocent G, Pal A, 2016. Ligand-based virtual screening and ADME-TOX guided approach to identify natural compounds from Conyza sumatrensis (retz.) E.H. Walker as cox-2 inhibitors. International Journal of Pharmacy 6 (1) 62-70. Pone Kamdem B., Verma S, Singh H, Pandurang Daroka Mr, Srivastava SK, Pal A (2015). Bioactivity-guided isolation of antiplasmodial constituents from Conyza sumatrensis (Retz.) E.H. Walker. Parasitology International 64 (1) 118-123.DOI :https://doi.org/10.1016/j.parint.2014.10.010Pone Kamdem B., Verma S, Shukla A, Khan F, Srivastava SK, Pal A (2015).Membrane stabilization: A possible anti- inflammatory mechanism for the extracts and compounds from Spathodea campanulata. Natural Product Research28 (23): 2203-2207. DOI: 10.1080/14786419.2014.930858.Pone Kamdem B., Singh M, Verma S, Shukla A, Khan F, Srivastava SK, Pal A,(2015). RP-HPLC-DAD method for the identification of two potential antioxidant agents namely verminoside and 1-O-(E)- caffeoyl-β-gentiobiose from Spathodea campanulata leaves. Natural Product Research 29 (7) 676-680.DOI : 10.1080/14786419.2014.981538Pone Kamdem B., Pal A (2013). Susbtantiation of the ethnopharmacological use of Conyza sumatrensis in the treatment of malaria through in vivo evaluation in Plasmodium berghei K173 infected mice. Journal of Ethnopharmacology, 145 (1) 373-377.DOI : 10.1016/j.jep.2012.10.025Pone Kamdem B., Singh M, Maurya AK, Pal A (2013).Acute and sub-chronic toxicity of HPLC fingerprinted extract of Conyza sumatrensis in rodents. Journal of Ethnopharmacology, 149 (3) 833-837. DOI : 10.1016/j.jep.2013.07.006Pone Kamdem B., Singh M, Pal A (2014). HPLC-DAD fingerprinting of ethanol extracts from Conyza sumatrensis and Spathodea campanulata and their additive effect in Plasmodium berghei K173 infected mice. American Journal of Phytomedicine and Clinical Therapeutics 2 (6) 660-669. Pone Kamdem B., Telefo PB, Gouado I, Tchouanguep Mbiapo F (2012).Acute and subacute toxicity of the aqueous extract of leaves mixture of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis on albino Swiss mice and Wistar albino rats. Journal of Toxicology and Environmental Health Sciences 4 (7) 117-122. Ng M, Dalhatou S, Wilson J, Pone Kamdem B.,Bankole Temitote M, Kamdem Paumo H, Djelal H, Assadi AA, Nguyen-Tri P, Kane A (2022). Characterization of slaughterhouse wastewater and development of treatment techniques: A review. Processes. 2022, 10 (7),https://doi.org/10.3390/pr10071300Zimbili M, Pule Silent S, Paumo Kamdem H, Pone Kamdem B., Katata-Seru LM (2021). Enhanced antioxidant efficacy of nano- encapsulated Protorhus longifolia methanol extract stabilized with eudragit. International Journal of Nanoscience. 20, 2, https://doi.org/10.1142/S0219581X21500174Bongiwe D, Kamdem Paumo H, Pone Kamdem B.,Katata-Seru LM, Bahadur I(2022).Nanoengineered metab-based fertilizers : An innovative strategy for a more sustainable agriculture. Journal of Environmental Chemical Engineering 10(3). https://doi.org/10.1016/j.jece.2022.107729.

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